National AIDS Control Programme is being implemented through National AIDS Control Organization (NACO), New Delhi, under Ministry of Health & Family Welfare, Government of India with the support of DFID & World Bank fund. Accordingly autonomous organizations namely; State AIDS Control Societies have been formed in each of the States for smooth implementation of the programme. In Orissa, State AIDS Control Society has been working as the nodal agency for prevention & control of HIV/AIDS.

From 1992 - 1999 = National AIDS Control Programme, Phase - I (NACP-I) has been undertaken by Government of Orissa headed by Director, Health Services, Orissa.

From 1999 - 31.03.06 : -  Programme under NACP –II has been undertaken through Orissa State Health & Family Welfare Society in the name and style of State AIDS Cell (SAC).

From 14.07.2004 - onwards: - As per the direction of National AIDS Control Organization (NACO), a new Society, i.e., Orissa State AIDS Control Society (OSACS) was formed with. Hon’ble Minister,Health & Family Welfare Deptt. as President & the Chief Secretary, Orissa as Vice-President. It has been registered under Societies Act XXI of 1860 vide Regd. No. 21886/64 of 2004-2005.

The year 2007 has started on an important note for OSACS as the 3rd phase of National AIDS Control Programme (NACP-III) has beenlaunched from 6th of July, 2007. This programme builds on the attainment of the work of its previous NACP I & II.